VDR is a gene that codes for a vitamin D receptor protein. This protein regulates calcium absorption and bone development. A variant of the gene known as rs2228570 (FokI polymorphism), is associated with reduced bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by two components, and it is influenced by chromosomal locations and by binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes possess a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online storage facility for data and documents related to legal, business, or proceedings that are restricted in viewing printing, downloading, or viewing. It is accessed via a central computer as well as an extranet that is a restricted-access Internet connection, to allow users to log on at specific times.
VDRs are most commonly used by investment banks and businesses involved in mergers and gescheftmarketing.de/2021/12/20/what-are-the-risks-in-using-a-file-sharing-system-vs-a-data-room-service/ acquisitions. They require to communicate information in a clear manner with potential investors or buyers. The due diligence process can also require a large amount of information. Life science companies also utilize VDRs for everything from clinical trials results to HIPAA compliance documents.
